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Sharon Friefeld, Univ of Toronto, Toronto, Canada; Keith Oatley, Ontario Institute of Studies In Education, Toronto, Canada; Judy Friedland, Univ of Toronto, Toronto, Canada; Anderson Peter, Daune MacGregor, Rosalind Curtis, Gabrielle deVeber; Hosp for Sick Children, Toronto, Canada Background and Purpose: Stroke is unexpected during childhood years however occurs in 6 per 100, 000 per year. The effect of stroke on the quality of life QOL ; of children has not been assessed. The purpose of this study was to examine overall and domain specific QOL and it's predictors in children surviving stroke. Method: 1 ; One hundred and twelve children surviving arterial ischemic AIS ; stroke and cerebral sinovenous thrombosis CSVT ; between January 1996 2001 were assessed with the Centre for Health Promotion's CHP ; Quality of Life Profile, which was adapted for children in the current study. Children were assessed at a mean of 3 years range 17 years ; after stroke. The CHP assesses QOL in the domains of: physical and psychological health, environment and social relationships, and school and leisure activities. QOL is measured in terms of enjoyment and importance within each domain. 2 ; Predictor variables were tested including: age at event, gender, stroke type, lesion location and socioeconomic status utilizing univariate and multiple regression analyses. We also assessed the correlation among QOL, neurological deficits, and intellectual and functional deficits at a similar interval from stroke. Results: The CHP demonstrated a 'poor' QOL in 30% of children. Female gender, CSVT stroke type and older age at testing were significant predictors of reduced overall, and domain specific, QOL p .05 ; . Poor QOL scores correlated with the presence of cognitive and behavioral impairments and low verbal IQ. Cognitive behavior impairments had a greater effect on the QOL in older children and in females, especially in productivity i.e. school ; and socialization domains. Severity of neurological deficit, age at event, socioeconomic status, and functional deficits in daily living skills did not correlate on univariate analysis. Conclusions: QOL is reduced in children after stroke regardless of the presence or absence of physical neurological deficits. The CHP is a useful measure of QOL in these children. Predictors identified in this study are of clinical importance in identifying children at greatest risk for reduced QOL after stroke.
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